Advancements in flexible robotics, in-process control, equipment self diagnostics and self-correction. It may lead the way to next level without human.
In the near future the Restricted Access Barrier System will become more common in cleanrooms since it offers cost effective contamination improvements while still allowing human interventions. However, any form of intervention reduces control over microorganisms. While RABS interventions are controlled (with validated recovery times etc), they still pose some degree of risk.
In the early days of aseptic processing, gloveboxes were used to provide separation between the operator and "sterile field", providing greater control over microorganisms. In the 1950s, use of HEPA filters allowed development of clean rooms, where gowned personnel could operate equipment resulting in much greater throughput. However, isolation technology was reintroduced in 1980s as it was recognised as providing superior contamination control. Isolators were perceived as inflexible and had added requirements of leak testing and decontamination. Partial barriers were also used to provide a degree of separation in cleanrooms. This evolved into the restricted access barrier system.